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Since 1957 when IGF-1 and IGF-2 were identified and first designated as “sulfation factors” (156), the interest in the study of these molecules that structurally resembled proinsulin increased, especially when IGF-1 was found to be the mediator of the anabolic and mitogenic activity of GH (157)

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Rats Are Not Small Humans The animal data is impressive—I’ll give you that